Telmisartan – More than just a blood pressure medication

Telmisartan is the name of a drug that isn’t to common to bodybuilders, athletes or even just gym enthusiasts choosing to use performance enhancing drugs. The majority of steroid users have no idea what Telmisartan is or what it does. But they should. It could very well be one of the most important drugs available to AAS users who are concerned about their health.

Telmisartan is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. Lowering blood pressure can reduce the risk of strokes and heart attacks.

Telmisartan is an angiotensin II receptor blocker (ARB). It works by blocking a substance in the body that causes blood vessels to tighten. As a result, telmisartan relaxes the blood vessels. This lowers blood pressure and increases the supply of blood and oxygen to the heart. If selecting to self-medicate for moderate hypertension or borderline high blood pressure, Telmisartan is a great alternative to more traditional blood pressure lowering drugs.

Although it’s mainly known for being a prescription medication to lower BP, Telmisartan also has many, many other positive health benefits, especially for AAS users such as improving HDL cholesterol levels, metabolism, mitochondrial activity, endothelial function and cognitive function. Other advantages may include improving insulin sensitivity, decrease of risk of atherosclerosis, stroke and a potential advantage to brain health. In some instances mood or energy could be made better too.

In addition to blocking the RAS, Telmisartan also acts as a selective modulator of peroxisome proliferator-activated receptor gamma (PPAR-γ), a central regulator of insulin and glucose metabolism. It is believed that Telmisartan’s dual mode of action may provide protective benefits against the vascular and renal damage caused by diabetes and cardiovascular disease. It has also been shown to reduce left ventricular hypertrophy (LVH) and reduces visceral fat.

Following are some of the health benefit excerpts of various study findings with their relevant studies attached for reference:

Treatment of insulin resistance, diabetes and metabolic syndrome, whose activation is also correlated to anti-inflammatory and finally, anti-atherosclerotic properties.

Telmisartan shows peculiar features that go beyond blood pressure control. It presents promising and unique protective properties against target end-organ damage, potentially able to open a scenario of new therapeutic approaches to cardiovascular disease.

https://www.ncbi.nlm.nih.gov/pubmed/22077832

-In conclusion, these results suggest that Telmisartan is more effective at protecting renal function and vascular endothelial function, and at improving arteriosclerosis than the calcium channel blocker in patients with essential hypertension.

https://www.ncbi.nlm.nih.gov/pubmed/17137211

-There were significant reductions in visceral fat. In conclusion, Telmisartan treatment was associated with an improvement of vascular inflammation, reductions in visceral fat and increases in serum adiponectin.

https://www.ncbi.nlm.nih.gov/pubmed/18344626

-Telmisartan improves both hemodynamic and metabolic abnormalities found in hypertensive patients with obesity. The additional benefits may be partly due to visceral fat remodeling.

https://www.ncbi.nlm.nih.gov/pubmed/22008920

Telmisartan is a potent target for prevention and treatment in human prostate cancer.
https://www.ncbi.nlm.nih.gov/pubmed/18636189

We found a significant reduction of serum TC, HbA1c, hemoglobin and hematocrit and RBC count and a significant increase of serum potassium in ARB users, and a reduction of serum TC and hemoglobin in CCB users, from the baseline period to the exposure period. The reductions of RBC count, hemoglobin and hematocrit in ARB users were significantly greater than those in CCB users.

=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3416676/

There have been suggestions that valsartan may be more beneficial for competitive bodybuilders looking to step on stage as Telmisartan could cause some fat storage. I personally have not found this to be true, but I am also not looking to step on stage at 5% body fat. It is thought the increase in body fat could happen due to Telmisartan activating the PPAR-gamma which may work towards enhancing fat storage but I personally put a decrease in visceral fat high on the list of benefits, as well as reduction in LVH, RBC, and all the other health benefits mentioned above which included increasing PPAR-delta, GLUT4, UCP1, SIRT1, AMPK, HDL, phospho-AMPK-α, hormone lipase, adiponectin, leptin, CRP, IL-1β, and fatty acid oxidation in muscle; decreasing aldosterone, TNFα, LDL, serum triglycerides, inflammation in adipose tissue, and fasting blood glucose; and inhibiting adipogenesis. All these can actually be helpful activities for fat loss!

Bill Roberts also thought if you were a competitive bodybuilder aiming to step on stage, the storing of body fat may be an issue but is unlikely due to Telmisartan’s many activities working against fat storage that overall it’s unlikely you will gain body fat from the PPAR-gamma mechanism, but something worth considering none the less. He has suggested using Oleuropein supplementation that can work towards blocking this activation, so he suggested this supplement to use in combination with Telmisartan. I personally dont bother. He also mentioned the other undesired activity is partial blocking of the 1,25-dihydroxyvitamin-D receptor and would address this with supplementation of Vitamin D.

Finally, Telmisartan must not be utilized together with a diuretic and avoid serious dehydration while using this drug.

Dosages range from 20mg -160mg a day. I have found 40mg a day to be beneficial while on a cruise/TRT with minimal to no side effects and often bump that to 80mg while on cycle.

Contributed to the bs-board community by SimonMyers.

https://bs-board.org/forum/index.php?threads/telmisartan-more-than-just-a-blood-pressure-medication.250992/#post-312118

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